Wenyuan Shi, Ph.D.
Wenyuan Shi, Ph.D. obtained his BS degree from Fudan University (Shanghai) in 1984, acquired his Ph.D degree from University of Wisconsin-Madison in 1991 and fulfilled his postdoctoral training at University of California at Berkeley during 1992-1995. Dr. Wenyuan Shi is a chair and professor of the Section of Oral Biology at the UCLA Schools of Dentistry. He is co-author and co-inventor of over 200 scientific articles and patents.
|UCLA School of Dentistry
10833 Le Conte Avenue
Los Angeles, CA 90095-1668
|Phone: (310) 825-8356
Fax: (310) 794-7109
Education & Professional Background
- 1984, B.S., Genetics, Fudan University, Shanghai, P. R. C.
- 1991, Ph.D., Genetics, University of Wisconsin-Madison
- 1986-1991, Ph.D Graduate Student, Department of Genetics, University of Wisconsin-Madison
- 1992-1995, Postdoctoral researcher and assistant research microbiologist, Department of Molecular and Cell Biology, University of California-Berkeley
- 1995-2000, Assistant professor, School of Dentistry and Molecular Biology Institute (MBI), UCLA
- 2000-2002, Associate professor, School of Dentistry and MBI, UCLA
- 2002-present, Professor, School of Dentistry and MBI
- 2002-present, Professor, Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, UCLA
- 2002-present, Director, UCLA Dental Research Service Center
- 2003-present, Director, UCLA Oral Biology Ph.D program
- 2004-present, Chairman, Section of Oral Biology, UCLA School of Dentistry
- Course chair, Molecular and Cellular Biology
- Course chair, Bacterial pathogenesis
- Course chair, Microbial signal transduction
- Course chair, Microbial motility/chemotaxis and pathogenesis
Research and Interests
Dr. Shi’s laboratory has been using multidisciplinary approaches to study oral microbial pathogenesis with a specific focus on microbial biofilm, inter-species interaction and signal transduction. In addition, Dr. Shi’s laboratory is actively involved in the development of next generation of diagnostic and therapeutic tools against oral microbial infections, including instant chairside detection of oral pathogens and peptide based targeted antimicrobial therapeutics.
Representative Publications (out of 180 papers)
1. W. Shi and R. Lux. 2007. Focal adhesion – getting a grasp on myxobacterial gliding. Nature Chemical Biology, Vol. 3, p205-206.
2. Li, L., J. He, R. Eckert, D. Yarbrough, R. Lux, M. Anderson, and W. Shi. 2010. Design and characterization of an acid-activated antimicrobial peptide. Chem Biol Drug Des. Vol. 75, 127-132.
3. Kaplan CW, Ma X, Paranjpe A, Jewett A, Lux R, Kinder-Haake S and W. Shi. 2010. Fusobacterium nucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes. Infect. Immun. Vol. 78, p4773-4778.
4. Sullivan, R., P. Santarpia, S. Lavender, E. Gittins, Z. Liu, M.H. Anderson, J. He, W. Shi and R. Eckert. 2011. Clinical efficacy of a specifically targeted antimicrobial peptide mouth rinse: targeted elimination of streptococcus mutans and prevention of demineralization. Caries Res. Vol 45, p415-28. Epub 2011.
5 . Eckert, R., R. Sullivan, W. Shi. 2012. Targeted antimicrobial treatment to re-establish a healthy microbial flora for long-term protection. Adv. Dent. Res. Vol. 24, p94-7.
1987- present, American Society of Microbiology
- 1995- present, American Association for the Advancement of Science
- 1996-present, American Association for Dental Research