C. Julie Chang, Ph.D.
Adjunct Assistant Professor
Phone:
(310) 267-3340
Address:
UCLA School of Dentistry
10833 Le Conte Ave.
Box 951668
Los Angeles, CA 90095-1668
Office:  33-030 CHS

Biography

C. Julie Chang has been promoted to Adjunct Assistant professor after joining School of Dentistry from the University of Texas McGovern Medical School. She is an experienced molecular microbiologist and has been studied bacterial pathogenesis with Dr. Ton-That since 2009 in the Department of Microbiology and Molecular Genetics. She has served as an important role in supervising graduate and postgraduate students and laboratory management. Additionally, she has led and collaborated in many research projects, whose results were published in highly respected peer-reviewed journals.

Educational & Professional Background

  • B.S. in Biology, Tunghai University, Taichung, Taiwan, 1984

  • Ph.D. in Microbiology, Texas A&M University, College Station, Texas, 1994

Research & Interests

  • Oral Bacterial Pathogenesis

  • Protein Biochemistry and Engineering

  • Innovation for Therapeutical Treatment of Oral and Dental Diseases

Professional Memberships

  • American Society for Microbiology

Awards

  • U.S. Patent No. 5,777,078: “Triggered Pore Forming Agents”

Representative Publications

  • Chang, C., Amer, B. R., Osipiuk, J., McConnell, S. A., Huang, I-H., Hsieh, V., Fu, J., Nguyen,H.H., Muroski,J., Flores, E., Ogor-zalek Loo, R.R., Loo, J. A., Putkey, J. A., Joachimiak, A., Das, A., Clubb, R.T. and Ton-That, H. In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin crosslinking. Proc Natl Acad Sci 115(24): E5477-E5486. (2018)

  • McConnell, S.A., Amer, B. R., Muroski,J., Fu, J., Chang, C., Ogor-zalek Loo, R.R., Loo, J. A., Osipiuk, J., Ton-That, H. and Clubb, R.T. Protein labeling via a specific lysine-isopeptide bond using the pilin polymerizing sortase from Corynebacterium diphtheria. J Am Chem Soc.140(27):8420-8423. (2018)

  • Sanchez, B.C.*, Chang, C.*, Wu, C., Tran, B. and Ton-That, H. (2017) Electron transport chain is biochemically linked to pilus assembly required for polymicrobial interactions and biofilm formation in the Gram-positive Actinobacterium Actinomyces oris. MBio 8(3). *These authors contributed equally to this work. (2017)

  • Echelman, D., Alegre-Cebollada, J., Badilla, C.L., Chang, C., Ton-That, H. and Fernández, J.M. Cna-A domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci 113(9):2490-5. (2016)

  • Chang. C., Hung, I-H, Hendrickx, A. and Ton-That, H. Visualization of Gram-positive Bacterial Pili in the Bacterial Cell Surface, Methods in Molecular Biology, Ed. Anne Delcour 966: 77-95, Humana Press. (2013)