Research News

Posted on: Monday, 04/15/2019

New class of membranes shown to regenerate tissue and bone, viable solution for periodontitis

Dr. Alireza Moshaverinia, assistant professor of prosthodontics, and collaborator, Dr. Paul Weiss, distinguished professor of chemistry and biochemistry at UCLA, published a study in ACS Nano on how they successfully developed a more effective and reliable therapy for periodontal disease. The team created a new class of periodontal membranes that, when implanted, can deliver drug therapies to the infected area and also adhere to a range of surfaces in the mouth. The researchers see this application extending beyond periodontitis treatment to other areas needing expedited wound healing and prolonged drug delivery therapeutics. For the full press release. Read the entire study.


Early cancer detection liquid biopsy technology receives regulatory approval

Dr. David Wong, associate dean for research, and his research team received regulatory approval on their EFIRM (electric field-induced release and measurement) technology as a Clinical Laboratory Improvement Amendments (CLIA)-certified, College of American Pathology (CAP)-accredited assay to be used in clinical practice. EFIRM creates a reliable, novel, and impactful method to detect tumor-causing, lung cancer mutations in saliva and blood that is non-invasive, cost-effective, and quick.

EFIRM Regulatory Approval Celebration 

In another defining moment for liquid biopsy and salivary diagnostics, Dr. Wong was invited to speak on the EFIRM Liquid Biopsy technology in an NCI-sponsored session at the annual meeting for the American Association for Cancer Research in Atlanta, Georgia on April 2. In front of hundreds of cancer researchers from around the world, Dr. Wong presented in a session on the topic; “Liquid Biopsy: The Holy Grail for Early Cancer Detection.” Dr. Wong also chairs the steering committee of the NCI Liquid Biopsy consortium.

For the entire announcement.

Dr. Wong invited to speak at a cancer research event


Celebrating Our Research Accomplishments

The Office of Research held its annual Research Day on Wednesday, February 20, and welcomed keynote speaker Dr. Denise Aberle, professor of radiology and bionengineering and the vice chair for research, radiological sciences from the David Geffen School of Medicine at UCLA. Dr. Aberle presented on the topic; “Contemporary CT of the Indeterminate Lung Nodule.”

Following Dr. Aberle’s talk, winners of the poster competition, from the categories of dental students, residents, and graduate students, presented their research. Congratulations to the following winners:

Dental Student Category:

1st Place: Sara Zadmehr, Mentored by Drs. Renate Lux & Alireza Moshaverinia
2nd Place: Vadim Goldshtey, Mentored by Dr.Reuben Kim
3rd Place: Andrew Ikazaki, Mentored by Dr. Renate Lux

Master’s/Resident Category:

1st Place: Jiayu Shi, Mentored by Dr. Kang Ting
2nd Place: Moein Sadrkhani, Mentored by Dr.Shane White
3rd Place: Mikhail Izraylev, Mentored byDr. Igor Spigelman

PhD Candidate/Postdoctoral Fellow Category:

1st Place: Jingtao Li, Mentored by Dr. Cun-Yu Wang
2nd Place: Meng-Wei Ko, Mentored by Dr. Anahid Jewett
3rd Place: Akrivoula Soundia, Mentored by Dr. Sotirios Tetradis

Research Day 2019


New & Continuing Grants and Contracts (Jan. 1, - March 31, 2019)

New Grants
   
PI Name
Sponsor
Project Title
Total
Project Period
Sarah AnsariINTERNATIONAL ASSOCIATION OF DENTAL RESEARCHERS (IADR)A GROWTH- FACTOR- FREE ADHESIVE HYDROGEL FOR CRANIOFACIAL BONE TISSUE ENGINEERING$50,00007/01/19 - 06/30/21
Honghu LiuLOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR- UCLA MEDSHORT AND LONG TERM OUTCOMES OF DOXYCYCLINE VERSUS TMP- SMX FOR SSTI TREATMENT$45,02607/01/18 - 06/30/23
Daniela SilvaTHE NICHOLAS ENDOWMENTPROGRAM SUPPORT OF THE UCLA CHILDREN'S DENTAL CENTER$100,00001/03/19 - 12/31/19
Hung Ton-ThatNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHPOST- TRANSLOCATIONAL PROTEIN FOLDING IN GRAM- POSITIVE BACTERIA$277,92709/01/18 - 02/29/20
David WongNATIONAL CANCER INSTITUTE EFIRM- LIQUID BIOPSY (ELB): ULTRASENSITIVE CTDNA AND MIRNA DETECTION FOR EARLY ASSESSMENT OF LUNG CANCER$685,40309/13/18 - 07/31/23
  
Subtotal of new grants
$1,158,356
 
Continuing Grants
   
PI Name
Sponsor
Project Title
Total
Project Period
James CrallCA/DEPARTMENT OF HEALTH CARE SERVICES CALIFORNIA DEPARTMENT OF HEALTH CARE SERVICES - LA DENTAL PILOT PROJECT$7,915,28305/15/17 - 12/31/20
Jin Hee KwakNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHNOVEL SYSTEMIC PEGYLATED NELL- 1 THERAPY FOR CRANIOFACIAL OSTEOPOROSIS$158,22004/01/17 - 031/31/22
Renate LuxNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHSYSTEMATIC APPROACH TO EXPLORE THE MICROBIAL INTERACTOME$194,82309/01/17 - 08/31/19
Alireza MoshaveriniaOSTEO SCIENCE FOUNDATIONENGINEERING MICROSCALE DELIVERY SYSTEMS CAPABLE OF PRECISELY CONTROLLED GROWTH FACTOR RELEASE$50,00001/01/18 - 12/31/19
Taichiro NonakaNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHIMMUNOMODULATORY EFFECTS OF CYTOMEGALOVIRUS- INDUCED SALIVARY SOLUBLE FORM OF MHC CLASS I$156,00004/01/18 - 03/31/20
Francisco Ramos-GomezDHHS- HEALTH RESOURCES AND SERVICES ADMINISTRATION STRATEGIC PARTNERSHIPS FOR INTERPROFESSIONAL COLLABORATIVE EDUCATION IN PEDIATRIC DENTISTRY (SPICE- PD) $65,00007/01/15 - 06/30/20
Igor SpigelmanNEW YORK UNIVERSITYPERIPHERALLY- RESTRICTED CANNABINOIDS FOR CANCER AND CHEMOTHERAPY- INDUCED PAIN$184,46901/15/16 - 12/31/19
Hung Ton-ThatNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHPOST- TRANSLOCATIONAL PROTEIN FOLDING IN GRAM- POSITIVE BACTERIA$355,74009/01/18 - 02/28/20
Cun-Yu WangNATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHMOLECULAR REGULATION OF MSC FATE DECISION AND BONE FORMATION BY PGC- 1A$442,45102/01/17 - 01/31/22
  
Subtotal of continuing grants
$9,521,986
 
 
 
 
 
 
 
 
TOTAL OF NEW & CONTINUING GRANTS & CONTRACTS
$10,680,342
 

 

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