Ki-Hyuk  Shin, M.S., Ph.D.
Adjunct Professor
Director of Preclinical Laboratory Operations
Phone:
(310) 267-2732
Address:
UCLA School of Dentistry
10833 Le Conte Ave.
Box 951668
Los Angeles, CA 90095-1668
Office:  43-019 CHS

Biography

Dr. Ki-Hyuk Shin is an adjunct professor in the Division of Oral Biology and Medicine at the UCLA School of Dentistry. He is an active member of Jonsson Comprehensive Cancer Center at the David Geffen School of Medicine at UCLA.

Educational & Professional Background

  • B.S., Korea University, 1990
  • M.S., UCLA, 1992
  • Ph.D., UCLA, 1995


Areas of expertise

  • Molecular Cancer Biology and Microbiology

Research & Interests

Dr. Shin’s' research program is founded on the question of how to identify and functionally define genetic and epigenetic alteration during oral carcinogenesis. This central theme has reached over time into three related areas: 1) the role of aberrant DNA repair activities in oral cancer; 2) the role of Human Papillomavirus in oral cancer; 3) the role of epigenetic regulators  in oral cancer; 4) the understanding of molecular characteristics of oral cancer stem cells; and 5) the mechanism of senescence in human oral keratinocytes.

 

Professional Memberships

  • Jonsson Comprehensive Cancer Center, Los Angeles, California
  • Dental Research Institute, UCLA School of Dentistry
  • American Association for Cancer Research
  • American Dental Association
  • International Association for Dental Research

Awards

  • Excellent Teaching Award -  presented by the UCLA Class of 2015
  • Most Memorable Lecture in Dental School Award - presented by the UCLA Class 2013
  • 1st place in UCLA SOD Research Day Competition in 2010 (Primary mentor of Amir Assefnia)
  • Finalists in the 2011 AADR Student Research Group DENTSPLY/Caulk
  • competition (Primary mentor of Yavuz Yildirim)
  • 2nd place in the 2011 American Association for the Advancement of Science
  • (AAAS) competition in oral biology and health sciences (Primary mentor of Rebecca Udokop)
  • 1st place in UCLA SOD Research Day Competition in 2012 (Primary mentor of Sung Hee Lee)

Representative Publications

Lee SH, Hong HS, Liu ZX, Kim RH, Kang MK, Park NH, Shin KH*. TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells.  Biochem. Biophys. Res. Commun, 424, 58-64, 2012

Shin KH, Bae SD, Hong HS, Kim RH, Kang MK, Park NH. miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochem. Biophys. Res. Commun, 404:896-902, 2011

Shin KH, KimRH, Kang MK, Kim R, Kim S, Lim PK, Yochim JM, Baluda MA Park NH. p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G.  DNA Repair, 6:830-840, 2007

Shin KH, Kang MK, Kim RH, Christensen R, Park NH. Heterogeneous nuclear ribonucleoprotein G (hnRNP G) demonstrates tumor suppressive effect against oral squamous cell carcinoma cells. Clinical Cancer Research, 12:3222-3228, 2006

Shin KH, Kang MK, Dicterow E, Kameta A, Baluda MA, Park NH. Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clinical Cancer Research, 10:2551-2560, 2004

Additional Information

Courses Taught:
  • OSD103, Foundations of Microbiology (Course chair)
  • OSD102, Oral & Systemic Disease I (Course faculty)
  • OSD105, Oral & Systemic Disease II (Course faculty)
  • OB201C, Advanced Oral Biology-Pathobiology (Course faculty)