No-Hee Park, D.M.D., Ph.D.
Dean Emeritus
Distinguished Professor of Dentistry
Distinguished Professor of Medicine
Phone:
(310) 825-7666
(310) 825-0339
Address:
UCLA School of Dentistry
10833 Le Conte Ave.
Box 951668
Los Angeles, CA 90095-1668
Office:  43-005 CHS

Biography

No-Hee Park, D.M.D., Ph.D. is a Dean Emeritus and a Distinguished Professor of Dentistry at the UCLA School of Dentistry and Distinguished Professor of Medicine at the David Geffen School of Medicine at UCLA.

“I chose UCLA because of its enormously rich intellectual environment and its geographic location at the Pacific rim. My vision for the UCLA School of Dentistry is to be the world leader in dental education. We have earned our exceptional reputation through exemplary and innovative learning, research, patient care, and public service programs. We are well on the way to achieving this vision through our world-class faculty and research, the high caliber of our students and our caring staff. Our teaching and research laboratories have been fully refurbished and our information technology has been fine-tuned. We are making our mark in grant awards and our research enterprise is one of the best in the world.  Students entering our School for the first year can rest assured that at the end of their four years, they will have received outstanding educations that will enable them to go anywhere in the field of dentistry. We will only get better and the vision I have for the UCLA School of Dentistry is well within our grasp."

Educational & Professional Background

Dr. No-Hee Park is a prominent scientist in oral and craniofacial research, with more than 180 scientific publications in distinguished research journals. His major research activities have been in oral (head &neck) cancer and aging research.  Dr. Park's contribution to the understanding of the mechanisms of oral cancer development is enormous, and resulted in new mode of therapy. In the early stage of his career (1975-1983), Dr. Park developed animal models to evaluate the therapeutic efficacy of antiviral agents and to study the molecular mechanisms of numerous antiviral agents (e.g., Zovirax®) against herpes simplex virus.

In later stages of his research career (since 1983), Dr. Park began to investigate the mechanisms of human oral cancer development. Initially, he found the combined carcinogenicity of herpes simplex virus (HSV: this virus causes cold sores around the human mouth) and cancer-causing chemicals found in tobacco. Then he investigated and clearly documented the combined role of tobacco (or chemical carcinogens derived from tobacco extract) and the virus on the development of oral cancer in laboratory animals. More recently, Dr. Park (1) developed an in vitro system (extremely useful for studying the mechanisms of oral cancer development) and clearly documented the role of human papillomavirus (HPV: this virus causes warts and may be related to other cancers) in the development of oral cancer; (2) clearly documented the close association between chromosome (cellular DNA) instability and cancer development; (3) developed many cell lines that are useful for cancer research; (4) documented a new aging model in test tubes, using cells derived from the human mouth; and (5) successfully converted normal human epithelial cells into mesenchymal cells, which were able to differentiate to bony cells and fat cells.  Currently his major interests are in the areas of cellular aging, molecular carcinogenesis and stem cell research. Through his cancer and aging research, Dr. Park has provided significant contributions to enhance the wellbeing of individuals and society, particularly by elucidating the role of human papillomavirus in the development of human cancer.

Dr. Park’s research has been well funded by both NIH and private foundations, and he has been a member of many research organizations, including American Association for Advanced Science (AAAS), American Association for Cancer Research (AACR), International Association for Dental Research (IADR), American Society for Microbiology (ASM), etc. He has also served on Editorial Boards for many research journals, including European Journal of Cancer (Oral Oncology), Journal of Dental Research, International Journal of Oncology, Journal of Biotechnology, Odontology, and International Journal of Oral Biology.  Additionally, for more than a decade, Dr. Park has served as a member of a number of NIH grant review committees for both the National Cancer Institute and the National Institute of Dental Research.

Dr. Park has received numerous awards and honors, and recognition by his peers, including the Distinguished Scientist Award from International Association for Dental Research (IADR), Alumnus of the Year Awards from Medical College of Georgia and Seoul National University (both School of Dentistry and University wide), the Award as the Most Achieved Dental Educator from the Gies /ADEA (American Dental Education Association) Foundation, the Silver Anniversary Award from Harvard University, No-Hee Park Endowed Chair at UCLA, Distinguished Professorship at UCLA, and AAAS (American Association for  Advancement of Science) Fellow, etc.

He has also trained more than 100 research students, postdoctoral fellows, and visiting faculty members from overseas during the past several decades.  Most of his trainees are presently faculty members of dental schools, medical schools and colleges of life science in the United States and many other countries including Korea, Japan and China.

Dr. Park received his DDS (Doctor of Dental Surgery) degree from the Seoul National University College of Dentistry in 1968 and a clinical certificate in Periodontics in 1971.  He received his PhD in Pharmacology in 1978 from the Medical College of Georgia, completed his postdoctoral fellowship at the Harvard Medical School-affiliated Eye Research Institute and earned his DMD (Doctor of Medicine in Dentistry) degree from the Harvard School of Dental Medicine in 1982. He then served two years as faculty at Harvard Medical School and Harvard School of Dental Medicine, before joining the faculty of the UCLA School of Dentistry in 1984. He became Director of the UCLA Dental Research Institute in 1995, where he served until June 2002, and in 1997, he was appointed Associate Dean for Research at the School of Dentistry and created the UCLA Wound Healing Research Center.

In 1998, Dr. No-Hee Park was named Dean of the UCLA School of Dentistry. He is still serving as Dean of the UCLA School of Dentistry and is also a Distinguished Professor of UCLA School of Dentistry and David Geffen School of Medicine at UCLA (UCLA School of Medicine). He was the first Korean-born American to be appointed dean in a major U.S. University. As Dean, Dr. Park directs a $75 million enterprise, with 400 full and part-time faculty, 450 students (DDS, PhD, and MS Programs), 91 dental residents, over 100 foreign clinical trainees, and a staff of 300 employees.

  • D.D.S., Seoul National University, Seoul, Korea, Dentistry, 1968

  • Certificate/M.S.D., Seoul National University, Seoul, Korea, Periodontics, 1971

  • Ph.D., Medical College of Georgia (Georgia Health Sciences University), Pharmacology, 1978

  • Postdoc., Harvard Medical School/Eye Research Institute, Virology/Mol. Biology, 1980

  • D.M.D., Harvard University, School of Dental Medicine, 1982

Research & Interests

Dr. No-Hee Park is a major scientist in the oral and craniofacial research community in the world with over 180 scientific publications in distinguished research journals. His major research activities have been in Oral (Head and Neck) Cancer research.  Dr. Park's contribution to the understanding of the mechanisms of oral cancer development is enormous, which resulted in a new mode of therapy. In the early stage of his career (1975-1983), Dr. Park developed animal models to evaluate the therapeutic efficacy of antiviral agents and studies the molecular mechanisms of numerous antiviral agents (e.g., Zovirax®) against herpes simplex virus.

In later stages of his research career (since 1983), Dr. Park began to investigate the mechanisms of human oral cancer development. Initially, he found the combined carcinogenicity of herpes simplex virus (HSV: this virus causes cold sores around the human mouth) and cancer causing chemicals found in tobacco. Then he investigated and clearly documented the combined role of smokeless tobacco (or chemical carcinogens derived from tobacco extract) and virus on the development of oral cancer in laboratory animals. More recently, Dr. Park (1) developed an in vitro system that is extremely useful for studying the mechanisms of mouth cancer development; clearly documented the role of human papillomavirus (HPV: this virus causes warts and may be related to other cancers) in the development of mouth cancer; (2) clearly documented the close association between chromosome (cellular DNA) instability and cancer development; (3) developed many cell lines that are useful for cancer research; (4) documented a new aging model in test tube, using cells derived from the human mouth; and (5) recently his group successfully converted normal human epithelial cells to mesenchymal cells which was able to differentiate to bony cells and fat cells.  Currently his major interests are in the area of cellular aging, molecular carcinogenesis, and atherosclerosis & periodontal diseases.

Professional Memberships

  • 1970 – Present:   International Association for Dental Research (IADR)

  • 1975 – Present:   American Association for the Advancement of Science

  • 1979 – Present:   American Association for Dental Schools (AADS) and American Dental Education Association (ADEA)

  • 1994 – Present:   American Association for Cancer Research

  • 1998 – 2016:   Member, UCLA Deans Council

  • 1998 – 2016:  ADEA (American Dental Education Association) Council of Deans Executive Committee

  • 2011 – 2016:  Board of Directors, Friends of National Institute of Dental and Craniofacial Research (FNIDCR)

Awards

  • 1978      NIH Research Fellowship Award

  • 1997    Honorary Doctor of Science” from Sejong University, Seoul, Korea

  • 2001    Distinguished Scientist Award, International Association for Dental Research (IADR), 

  • 2002    Distinguished Scientist in Natural Sciences, Korean Broadcasting System

  • 2002    The First Alumnus of the Year”, Seoul National University College of Dentistry

  • 2006    Awarded the title of “Distinguished Professor”, UCLA

  • 2007    Silver Anniversary Award”, Harvard School of Dental Medicine, Boston, MA

  • 2007    Distinguished Alumnus of the Year”, Seoul National University, Korea.

  • 2009    Dr. No-Hee Park Endowed Chair in Dentistry at the UCLA

  • 2010    The ADEA Gies Dental Educator Achievement Award

  • 2010    Distinguished Alumnus of the Year, Medical College of Georgia, Augusta, GA

  • 2012    AAAS Fellow

  • 2015    Honorary Alumnus of the Year 2015, UCLA School of Dentistry

  • 2016    Honorary Doctorate, Meikai and Asahi Universities

Representative Publications

Selected from more than 198 publications:

  • Non-canonical Wnt4 prevents skeletal aging and inflammation by inhibiting NF-κB. Nature Medicine, 20:1009-1017, 2014. PMID:25108526

  • The p63 Gene is regulated by Grainyhead-Like 2 (GRHL2) through reciprocal feedback and determines epithelial phenotype in human keratinocytes. Journal of Biological Chemistry, 290 (32):19999-20008, 2015. PMID 26085095

  • Regulation of p53 during senescence in normal human keratinocytes. Aging Cell 14:838-846, 2015. PMID: 26138448

  • Modeling the Etiology of P53-Mutated Cancer Cells. Journal of Biological Chemistry, 291:10131-10147, 2016. PMID: 27022024.

  • Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget 7:43239-43255, 2016. PMID 27259269

Additional Information

Courses Taught

• OSD106, Hematopoietic and Immunologic Disorders and Viral Diseases, UCLA School of Dentistry

• Course Chair, Dean’s Leadership Institute