Selected Publications

A. Original Articles

  1. Wang, C.-Y., Mayo, M.W., and Baldwin, A.S. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB*. Science 274:784-787. *One of ten discoveries cited by Science magazine in 199

  2. Mayo, M.M., Wang, C.-Y., Cogswell, P.C., Rogers-Graham, K.S., Lowe, S.W., Der, C.J., and Baldwin, A.S. 1997. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic RasScience 278:1812-1815 

  3. Wang, C.-Y.,* Mayo, M.M., Korneluk, R. G., Goeddel, D. V., and Baldwin, A.S*. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationScience 281:1680-1683. *Corresponding authors. Listed by the Scientist as a “hot paper”

  4. Wang, C.-Y., Cusack, J. Liu, R., and Baldwin, A.S. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaBNature Medicine 5:412-417.

  5.   Wang, C.-Y.*, Guttridge, D.C., Mayo, M.W., and Baldwin, A.S.* 1999. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosisMolecular and Cellular Biology 19:5923-5929. *Corresponding author.

  6. Guttridge, D.C., Mayo, M. W. Madrid, L.V., Wang, C.-Y., and Baldwin, A.S. 2000. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexiaScience 289:2363-2366.

  7. Chen, S. Guttridge, D.C., You, Z., Zhang, Z., Fribley, A., Kitajewski, J. Wang, C.-Y. 2001. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.* Journal of Cell Biology 152:87-96. *Featured by the journal editorial.

  8.  You, Z., S. Chen, D. Saims, Z. Zhang, K. Guan, O, Macdougall, G. Evan, M. Brown, J. Kitajewiski, and Wang, C.-Y. 2002. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.Journal of Cell Biology 157:429-440. *Featured by the journal editorial.

  9.  Shi, S., Gronthos, S., Chen, S., Counter, C., Robey, P.G., and Wang, C.-Y. 2002. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.*Nature Biotechnology 20:587-591. *Featured by the journal editorial.

  10.  Seo, B., Miura, M., Gronthos, S., Bartold, P.M., Batouli, S., Brahim, J., Young, M., Robey, P. G., Wang, C.-Y., and Shi, S.. 2004. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149-155.

  11.  Fribley, A., Zeng, Q., and Wang, C.-Y. 2004. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Molecular and Cellular Biology 24:9695-9704.

  12.  Zeng, Q. Li, S., Polverini, P., Nor, J. E., Kitajewski, J., and Wang, C.-Y. 2005. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8:13-23. Commented in the Journal’s Preview.

  13.  Zhang, H., Kim, J., Edwards, C.A., Xu, Z., Taichman, R., and Wang, C.-Y. 2005. Clusterin inhibits apoptosis by interacting with activated Bax. Nature Cell Biology 7:909-915. Cited by Faculty 1000.

  14.  Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q, Bennett, C., Harada, Y., Stankunas, K., Wang, C.-Y., He, X., MacDougald, O.A., You, M., Williams, B.O., and Guan, K.L. 2006. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Cell 126:955-968.

  15.  Park, B.K., Keller, E., McCauley, L., and Wang, C.-Y. 2007. NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nature Medicine 13:62-69. Cover story; News and Views in Nat Med; Research Highlight in Nature Reviews Cancer.

  16.  Zua, T, Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., Wang, Y., Liu, X., Chan, M., Liu, J., Park, B.K., Wang, C.-Y., Zheng, P., and Liu, Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129:1275-1286.

  17.  Li, J., and Wang, C.-Y. 2008. TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nature Cell Biology 10:160-169. Cited by Faculty 1000. Commented by Mol Cell.

  18.  Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J.D., Wang, C.-Y, Chinnaiyan, A.M., Lai, Z.C., and Guan, K.L. 2008. TEAD mediates YAP-dependent gene induction and growth control. Genes & Development 22:1962-1971.

  19.  Fan, Z., Yamaza, T., Lee, J.S., Yu, J. Wang, S., Fan. G. Shi, S, and Wang, C.-Y. 2009. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nature Cell Biology 11:1002-1009. PMCID: PMC2752141.

  20. Chang, J., Wang, Z., Tang, E., Fan, Z., McCauley, L., Franceschi, R., Guan, K., Krebsbach, P.H. and Wang, C.-Y. 2009. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nature Medicine 15:682-689. PMCID: PMC2768554.Commented in Research Highlights of Nature Reviews Rheumatology.

  21.   Song, H., Mak, K.K., Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R.M., Wang, C.-Y., Gao, B., Jiang, J., and Yang, Y. 2010 Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proceeding of National Academy of Science USA 107:1431-1436. PMCID: PMC2824397.

  22.  Zhao, B., Li, L., Wang, C.-Y., and Guan, K.L. 2010. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes and Development 24:72-85. PMCID: PMC2802193.

  23.  Ramadoss, S., Li, J., Ding, X., Al Hezaimi, K., and Wang, C.-Y. 2011. Transducin{beta}-Like Protein 1 Recruits Nuclear Factor {kappa}B to the Target Gene Promoter for Transcriptional Activation. Molecular and Cellular Biology 31:924-934.

B. Review Articles

  1. Rehman, A.O., and Wang, C.-Y. 2006. Notch signaling in the regulation of tumor angiogenesis. Trends in Cell Biology 16:293-300.

  2. Gronthos, S., Akintoye, S.O., Wang, C.-Y., and Songtao, S. 2006. Bone marrow stromal stem cells for tissue engineering. Periodontology 2000 41: 188-195.

  3. Fribley, A., and Wang, C.-Y.2006. Cancer Biology and Therapy 5:745-748  Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

  4. Fei, L. Kohlmeier, S, and Wang, C.-Y. 2008. Wnt signaling and skeletal development. Cellular Signaling 20:999-1009.

  5. Krum, S.A., Chang, J., Miranda-Carboni, G., Wang, C.-Y. 2010. Novel functions for NFκB: inhibition of bone formation. Nature Review Rheumatology 6:607-611.

  6. Teles, R., and Wang, C.-Y. Mechanisms involved in the association between peridontal diseases and cardiovascular diseaseOral Diseases In press. (Oral Dis. 2011 Jan 11. doi: 10.1111/j.1601-0825.2010.01784.x.