Selected Publications

Wang, C.-Y., Mayo, M.W., and Baldwin, A.S. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB*. Science 274:784-787. *One of ten discoveries cited by Science magazine in 199

Mayo, M.M., Wang, C.-Y., Cogswell, P.C., Rogers-Graham, K.S., Lowe, S.W., Der, C.J., and Baldwin, A.S. 1997. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812-1815 

Wang, C.-Y.,* Mayo, M.M., Korneluk, R. G., Goeddel, D. V., and Baldwin, A.S*. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683. *Corresponding authors. Listed by the Scientist as a “hot paper”

Wang, C.-Y., Cusack, J. Liu, R., and Baldwin, A.S. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nature Medicine 5:412-417.

  Wang, C.-Y.*, Guttridge, D.C., Mayo, M.W., and Baldwin, A.S.* 1999. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Molecular and Cellular Biology 19:5923-5929. *Corresponding author.

Guttridge, D.C., Mayo, M. W. Madrid, L.V., Wang, C.-Y., and Baldwin, A.S. 2000. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 289:2363-2366.

Chen, S. Guttridge, D.C., You, Z., Zhang, Z., Fribley, A., Kitajewski, J. Wang, C.-Y. 2001. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.* Journal of Cell Biology 152:87-96. *Featured by the journal editorial.

 You, Z., S. Chen, D. Saims, Z. Zhang, K. Guan, O, Macdougall, G. Evan, M. Brown, J. Kitajewiski, and Wang, C.-Y. 2002. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.* Journal of Cell Biology 157:429-440. *Featured by the journal editorial.

 Shi, S., Gronthos, S., Chen, S., Counter, C., Robey, P.G., and Wang, C.-Y. 2002. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.*Nature Biotechnology 20:587-591. *Featured by the journal editorial.

 Seo, B., Miura, M., Gronthos, S., Bartold, P.M., Batouli, S., Brahim, J., Young, M., Robey, P. G., Wang, C.-Y., and Shi, S.. 2004. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149-155.

 Fribley, A., Zeng, Q., and Wang, C.-Y. 2004. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Molecular and Cellular Biology 24:9695-9704.

 Zeng, Q. Li, S., Polverini, P., Nor, J. E., Kitajewski, J., and Wang, C.-Y. 2005. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8:13-23. Commented in the Journal’s Preview.

 Zhang, H., Kim, J., Edwards, C.A., Xu, Z., Taichman, R., and Wang, C.-Y. 2005. Clusterin inhibits apoptosis by interacting with activated Bax. Nature Cell Biology 7:909-915. Cited by Faculty 1000.

 Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q, Bennett, C., Harada, Y., Stankunas, K., Wang, C.-Y., He, X., MacDougald, O.A., You, M., Williams, B.O., and Guan, K.L. 2006. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Cell 126:955-968.

 Park, B.K., Keller, E., McCauley, L., and Wang, C.-Y. 2007. NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nature Medicine 13:62-69. Cover story; News and Views in Nat Med; Research Highlight in Nature Reviews Cancer.

 Zua, T, Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., Wang, Y., Liu, X., Chan, M., Liu, J., Park, B.K., Wang, C.-Y., Zheng, P., and Liu, Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129:1275-1286.

 Li, J., and Wang, C.-Y. 2008. TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nature Cell Biology 10:160-169. Cited by Faculty 1000. Commented by Mol Cell.

 Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J.D., Wang, C.-Y, Chinnaiyan, A.M., Lai, Z.C., and Guan, K.L. 2008. TEAD mediates YAP-dependent gene induction and growth control. Genes & Development 22:1962-1971.

 Fan, Z., Yamaza, T., Lee, J.S., Yu, J. Wang, S., Fan. G. Shi, S, and Wang, C.-Y. 2009. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nature Cell Biology 11:1002-1009. PMCID: PMC2752141.

Chang, J., Wang, Z., Tang, E., Fan, Z., McCauley, L., Franceschi, R., Guan, K., Krebsbach, P.H. and Wang, C.-Y. 2009. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nature Medicine 15:682-689. PMCID: PMC2768554.Commented in Research Highlights of Nature Reviews Rheumatology.

  Song, H., Mak, K.K., Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R.M., Wang, C.-Y., Gao, B., Jiang, J., and Yang, Y. 2010 Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proceeding of National Academy of Science USA 107:1431-1436. PMCID: PMC2824397.

 Zhao, B., Li, L., Wang, C.-Y., and Guan, K.L. 2010. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes and Development 24:72-85. PMCID: PMC2802193.

 Ramadoss, S., Li, J., Ding, X., Al Hezaimi, K., and Wang, C.-Y. 2011. Transducin{beta}-Like Protein 1 Recruits Nuclear Factor {kappa}B to the Target Gene Promoter for Transcriptional Activation. Molecular and Cellular Biology 31:924-934.